Formulation And Development Lab-II


Research Overview: To formulate and optimize controlled drug delivery systems.

Focus Area: Topical gel formulation, Floating drug delivery system, Microencapsulation

 Faculty involved:

  • Dr. (Mrs.) S. Pattnaik, Assoc. Professor
  • Dr. Mrs. Snehamayee Mohapatra, Asst. Professor
  • Mrs. Sangeeta Mohanty, Asst. Professor

Res. Scholar Involved:

  • Mr. P. Niyogi
  • Mrs. Sabitri Bindhani

 Projects:

‘Inspire Fellowship Project’ entitled “Formulation and Evaluation of Various Novel Mucoadhesive Oral/Buccal Drug Delivery System Containing API for the Treatment of Oral/Buccal Infectious Dieses’’ approved from DST, New Delhi.

‘University Research Fellow’ entitled “Super Saturated Self Emulsifying Drug Delivery Systems for Selected Drugs”

PUBLICATIONS:

Dr. Snigdha Pattnaik

International:

  1.  Rishikesh Gupta, SK Prajapati, Snigdha Pattnaik, Peeyush Bhardwaj. Intend, Depiction In Vitro and In Vivo Appraisal of Glipizide Floating Microspheres using Ethyl Cellulose and Hydroxyl Propyl Methyl Cellulose s Polymer by Substantially Modified Method. Asian Journal of Pharmaceutical and Clinical Research, 9 (5), Aug-Sept-2016: 1-5. [ISSN: Online - 2455-3891; Print - 0974-2441] [Indexed in SCOPUS, SCImago Impact – 0.48].
  2. Niyogi Partha, Pattnaik Snigdha, Maharana Laxmidhar. Formulation Development and In Vitro Evaluation of Dental Gel Containing Ethanol Extract of Tephrosia Purpurea Linn. International Journal of Pharmacy and Pharmaceutical Sciences, 8(8), Aug-2016: 132-141. [ISSN- 0975-1491] [Indexed in SCOPUS, SCImago Impact – 0.49]
  3. Partha Niyogi, Snigdha Pattnaik and Laxmidhar Maharana. Quantitative Identification of Major and Minor constituents of Aerial parts of Mollugo pentaphylla Linn. using GC-MS. Asian Journal of Chemistry, June-2016, 28 (10): 2335-2338. [ISSN: 0975-427X] [Indexed in SCOPUS, SCImago Impact – 0.14]
  4. Snigdha Pattnaik, Sukanya Priyadarshini, Partha Niyogi, Laxmidhar Maharana. Formulation and Evaluation of Microencapsulated Levofloxacin Gel. Research & Reviews: A Journal of Drug Formulation, Development and Production. 3 (1), April-2016: 39-47 [ISSN: 2394-1944(online)].
  5. Satyajit Panda, Krishna Praneeth R., Venugopal M., Snigdha Pattnaik and Laxmidhar Maharana. Formulation and evaluation of domperidone embedded floating matrix tablets using various release retardants from natural and synthetic origin. Journal of Chemical and Pharmaceutical Research, Oct-2015, 7(10): 200-207. ISSN: 0975-7384. [Indexed in SCOPUS, SCImago Impact - 0.2]
  6. Satyajit Panda, Varadi Latha, Snigdha Pattnaik, Laxmidhar Maharana, Ranjit Prasad Swain. An Update on Various Excipients Employed for Orodispersible Tablets with A Special Focus on Super disintegrants. International Journal of Pharmaceutical and Clinical Research. Oct-2015; 7(6): 440-449.  ISSN- 0975 1556. [Indexed in SCOPUS, SCImago Impact – 0.16]
  7. Satyajit Panda, Sv Vijayalakshmi, Snigdha Pattnaik, Ranjit Prasad Swain. Nanosponges: A Novel Carrier for Targeted Drug Delivery. International Journal of PharmTech Research. Vol.8, No.7, pp 213-224, July 2015. ISSN: 0974-4304. [Indexed in SCOPUS, SCImago Impact - 0.37]
  8. Rishikesh Gupta, Sunil Kumar Prajapati, Snigdha Pattnaik, Peeyush Bhardwaj. Design, Evaluation and Radiographic study of Novel Floating film bearing Famotidine as a model drug. Latin American Journal of Pharmacy, 34(5), May-2015: 917-923. [Indexed in SCOPUS, Impact Factor - 0.334].
  9. Rishikesh Gupta, Sunil Kumar Prajapati, Snigdha Pattnaik. Design and evaluation of floating microspheres for site specific drug delivery in stomach and its radiographic studies. Latin American Journal of Pharmacy, 34(4), April-2015: 652-660 [Indexed in SCOPUS, Impact Factor - 0.334].
  10. Satyajit Panda, Snigdha Pattnaik, Laxmidhar Maharana, Anjan K. Mahapatra. Formulation and Evaluation of Zidovudine Loaded Biodegradable Microcapsules Employing Sterculia Gum by Emulsification-Internal Gelation Technique. Latin American Journal of Pharmacy, Sept-2014, 33 (9): 1454-62. ISSN: 2362-3853. [Indexed in SCOPUS, Impact Factor - 0.334].
  11. Snigdha Pattnaik, Niyogi Partha, Maharana Laxmidhar, Panigrahi Lalatendu. Formulation, Evaluation And Solid-State Thermographic Characterization Of CFC Free Beclometasone Dipropionate Pressurized Metered Dose Inhalation.  International Journal of Pharmacy and Pharmaceutical Sciences, 6 (8), Aug-2014: 398-403. [ISSN: 0975–1491] [Indexed in SCOPUS, SCImago Impact - 0.91].
  12. Satyajit Panda, Snigdha Pattnaik, Laxmidhar Maharana, Chintapalli Kavya Teja, Debajyoti Das. HIV and AIDS: Need of an Effective Drug Delivery, Research J. Pharm. and Tech. 7(6): June 2014; Page 686-694. ISSN 0974-360X (online) ISSN 0974-3618 (print), [Indexed in SCOPUS, SCImago Impact - 0.12]
  13. Rishikesh Gupta, Sunil Kumar Prajapati, Snigdha Pattnaik, Peeyush Bhardwaj, Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study. Asian Pacific Journal of Tropical Biomedicine. Sept-2014; 4(9): 930-937. (Elsevier), [Indexed in SCOPUS, Impact Factor - 0.31, SNIP-1.171].
  14. Santosh Kumar, Rishikesh Gupta, Dr. S. K. Prajapati, Nikhil Gupta, Snigdha Pattnaik and Ashu Agrawal. Proniosomes formulation and evaluation by slurry method as an emerging provesicular drug carrier in NDDS. World Journal Pharmacy and Pharmaceutical Science, (ISSN: 2278-4357). Sept-2014; 3(9): 275-294.
  15. Satyajit Panda, Snigdha Pattnaik, Laxmidhar Maharana, Girish Babu Botta, Anjan K Mahapatra. Design and Evaluation of Zidovudine Loaded Natural Biodegradable Microcapsules Employing Colophony Resin as Microencapsulating Agent. International Journal of Pharmacy and Pharmaceutical Sciences, (ISSN- 0975-1491), Vol 5, Issue 3, 2013: 799-805. [Indexed in SCOPUS, SCImago Impact - 0.91].
  16. Satyajit Panda, Snigdha Pattnaik, Laxmidhar Maharana, Girish Babu Botta, Prithwiraj Mohapatra. Formulation And Evaluation Of Zidovudine Loaded Olibanum Resin Microcapsules: Exploring The Use Of Natural Resins As Biodegradable Polymeric Materials For Controlled Release. Asian J. of Pharmaceutical and Clinical Research (ISSN - 0974-2441), Vol 6, Issue 3, 2013:191-196. [Indexed in SCOPUS, SCImago Impact - 0.7].
  17. Satyajit Panda, Girish Babu Botta, Snigdha Pattnaik, Laxmidhar Maharana. A complete review on various natural biodegradable polymers in pharmaceutical use. Journal of Pharmacy research (Elsevier) (ISSN: 0974-6943). 5(12), 2012: 5390-5396.
  18. Rishikesh Gupta, S.K. Prajapati, Snigdha Pattnaik, Apoorva Ganguli, Sapna Mishra. Performance and evaluation of floating microspheres of famotidine and comparison of their physical properties. International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 5, Dec 2012: 376-382. [Indexed in SCOPUS, SCImago Impact - 0.91].
  19. Tutun Mitra, Dr. Snigdha Pattnaik, Dr. J.Panda, Dr. Prafulla Kumar Sahu, B.K.Rout, P Sri Rama Murthy and R. K. Sahu. Formulation and Evaluation of salbutamol sulphate mucoadhesive sustained release tablets using natural excipients. Journal of Chemical and Pharmaceutical Sciences, (ISSN: 0974-2115). Vol-5; Issue-2, 2012. [SCImago Impact - 0.1]
  20. Laxmidhar Maharana, Snigdha Pattnaik, Durga Madhab Kar. Antidiabetic evaluations of aqueous extract of aerial parts of Mollugo pentaphylla L. Int. J. of Pharmacy and Pharmaceutical Sciences (ISSN- 0975-1491). 4 (4), 2012: 269-275. [Indexed in SCOPUS, SCImago Impact - 0.91].
  21. Laxmidhar Maharana, Snigdha Pattnaik, Durga M. Kar, Pratap K. Sahu, Sudam C. Si. Assessment of Antihyperglycemic and antioxidant potential of leaves of Solanum nigrum Linn. in alloxan induced diabetic rats. Pharmacologyonline (ISSN: 1827-8620), 1: 942-963, 2011. [Indexed in SCOPUS, SCImago Impact - 0.39]
  22. Laxmidhar Maharana, Snigdha Pattnaik, Durga M. Kar, Pratap K. Sahu, Sudam C. Si. Antioxidant activity of aqueous extract of aerial parts of Mollugo pentaphylla linn. An invitro study, Pharmacologyonline (ISSN: 1827-8620), 3: 982-997 (2010). [Indexed in SCOPUS, SCImago Impact - 0.39]
  23. Laxmidhar Maharana, Durga M. Kar, Snigdha Pattnaik, Pratap K. Sahu, Sudam C. Si.. In Vitro Antioxidant Activity of Aqueous Leaf Extract of Solanum Nigrum Linn. Pharmacologyonline (ISSN: 1827-8620), 3: 333-345 (2010).[Indexed in SCOPUS, SCImago Impact - 0.39]
  24. Laxmidhar Maharana, Snigdha Pattnaik, Durga M. Kar, Pratap K. Sahu, Anti-Hyperglycemic potential of aqueous extract of leaves of Solanum nigrum Linn, Sudam C. Si, Der Pharmacia Lettre, (ISSN 0974-248X) 2010, 2(3): 168-179. [Indexed in EBSCO, SCImago Impact - 0.5]
  25. Laxmidhar Maharana, Snigdha Pattnaik, Durga M. Kar, Pratap K. Sahu and Sudam C. Si, Study of hypoglycemic potential of aqueous extract of aerial parts of Mollugo pentaphylla Linn, Annals of Biological Research, (ISSN 0976-1233) 2010, 1 (2) :155-165. [Indexed in EBSCO]
  26. Snigdha Pattnaik, Lalatendu Panigrahi, Rayasa S. R. Murthy, “Periodontal Muco-adhesive Formulations for the Treatment of Periodontal Infectious Diseases”, Current Drug Delivery, Vol No.4, Issue No.4, 2007. (Bentham Science publisher) (Impact Factor– 2.248, SCImago Impact -2.55).
  27. D.M.Kar, L.Maharana, S.Pattnaik and G.K.Dash, Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad and Wendl fruit extract in rats. Journal of Ethnopharmacology, Elsevier, Netherland, Feb-2006, Vol. 108, no. 2, pp.251 -256. [Indexed in SCOPUS, Impact Factor– 3.01]
  28. Lalatendu Panigrahi, Snigdha Pattnaik, S.K.Ghosal, “The Effect of pH and Organic Ester Penetration Enhancer on Skin Permeation Kinetics of Terbutaline Sulphate from Pesudolatex-Type Transdermal Delivery Systems Through Mouse and Human Cadaver Skins”. AAPS PharmSciTech, 6 (2), 2005, 167-173. [Indexed in SCOPUS, Impact Factor – 1.776]
  29. Lalatendu Panigrahi, Snigdha Pattnaik, Saroj K. Ghosal, “Design and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate”, Acta Poloniae Pharmaceutica-Drug Research, 2004, 61, 351-360.  [Indexed in SCOPUS]
  30. D.Sasmal, A.K.Pattnaik, S.Pattnaik and D.M.Kar, Hamdard medicus (ISSN. 0250-7188), Hepatoprotective activity of Urtica parviflora Roxb, Vol.XLX issue no. 1, of Jan-Mar. 2007.
  31. D.M.Kar, M.K.Kar, Pattnaik Snigdha, S.M.A.Alli and G.K.Dash, Studies on the antiulcer activity of Mirabilis jalapa Linn. Hamdard medicus (ISSN. 0250-7188), 2005, XLVIII (3).
  32. D. M. Kar, A. Dinda, M. Banerjee, S. Pattnaik, G. K. Dash, Synthesis and Pharmacological screening of 1,3-substituted Indolin-2-one for Anti-inflammatory and Antibacterial activity, Journal of Teaching and Research in chemistry, 2004,11(1), pp 83-89.

 National:

  1. L. Maharana, S. Pattnaik, D. M. Kar. In Vitro antioxidant activity of aqueous fruit extract of Solanum xanthocarpum Schrad. & Wendl. The Research Network. VII (4), December 2012: 23-33. ISSN 0975 0517.
  2. S. Pattnaik, L. Maharana. A Retrospective approach to Ageing Process. The Research Network. VII (4), December 2012: 09-16. ISSN 0975 0517. (Review Article)
  3. S.Pattnaik, L.Maharana, R.S.R. Murthy. Formulation and in-vitro in-vivo Evaluation of Cytarabine loaded thermo-sensitive hydrogel containing chitosan. The Research Network, ISSN 0975-0517, V (1), March, 2010; pp: 12-20.
  4. L.Panigrahi, S.K.Ghosal, Snigdha Pattnaik, L.Maharana, B.B.Barik, “Effect of Permeation Enhancers on the Release and Permeation kinetics of Lincomycin Hydrochloride Gel Formulations through Mouse Skin” Indian Journal of Pharmaceutical Sciences, (ISSN- 0250-474X), March-April, 2006, 205-211. [Indexed in SCOPUS, Impact factor – 0.338]
  5. L.Panigrahi, Snigdha Pattnaik, S.K.Ghosal, “Design and Characterization of Mucoadhesive Buccal Patches of Diclofenac Sodium”, Indian Journal of Pharmaceutical Sciences, 2005, 67 (3): 319-326. [Indexed in SCOPUS, Impact factor – 0.338]
  6. L.Panigrahi, Snigdha Pattnaik, S.K.Ghosal, “Permeation Kinetics of Diclofenac Sodium from Pseudolatex Transdermal Formulations through Lipidized and Delipidized Mouse Skin”, Indian Journal of Pharmaceutical Sciences, January-February, 2005, 124-127.  [Indexed in SCOPUS, Impact factor – 0.338]
  7. D. M. Kar, Snigdha Pattnaik, L. Maharana and G. K. Dash., Hepatoprotective activity of water Chestnut Fruit, Indian Journal of natural products, 2004, 20(3), pp.17-21.
  8. Snigdha Pattnaik, L. Panigrahi, S.K.Ghosal, “Incompatibility and Usefulness of Vitamins – Recent Views, Journal of Science and Pharmacy, Vol- 5, No.-1, Jan- Mar 2004, 16-28.
  9. Lalatendu Panigrahi, S.Pattnaik, S.K.Ghosal, “Limulus Amebocyte Lysate Test”, Indian Journal of Pharmaceutical Education, 37(2) April-June 2003, 88-93.

Mrs. Snehamayee Mohapatra

  1. Formulation and evaluation of Celecoxib suspension with β-cyclodextrin. Journal of Teaching and Research in Chemistry. Vol. 13.No.2.2006.
  2. Analgesic and Antibacterial activity of leaves of Vatex negundo. Journal of Teaching and Research in Chemistry. Vol. 13.No.2.2006.
  3. Formulation and evaluation of Celecoxib suspension with β-cyclodextrin. Journal of Teaching and Research in Chemistry. Vol. 13.No.2.2006.
  4. Formulation and In-vitro evaluation of Hydrophilic Matrix Tablets of Isosorbide-5-mononitrate Using Different Viscosity Grades of HPMC, Acta Pharmaceutica Sciencia,51: 39-46 (2009)
  5. Formulations and Statistical Optimization of Intra Gastric Floating Matrix Tablets of Cefuroxime Axetil, Journal of Pharmacy Research, Vol.2.Issue 9.Septmber 2009.
  6. Design and Characterization of Controlled Release Matrix Tablets of Zidovudine, Asian journal of Pharmaceutical and Clinical Research (AJPCR), Vol.2, Issue.2, April-June, 2009(54-61).
  7. Formulation and Statistical Optimization of Controlled Release Matrix Tablet of Zidovudine R.K. Kar, S. Mohapatra, P. Mohapatra, S.B. Bhanja and B.B. Barik Asian J. Chem., Vol. 22, pp. 1896-1906 (2010)
  8. Formulation and In Vitro Characterization of Xanthan Gum Based Sustained Release Tablets of Isosorbide-5-Mononitrate, Iranian Journal of Pharmaceutical Research, Iranian J Pharm Res 2010: 9 (1): 13-19.
  9. Preparation and in vitro Characterization of Cefuroxime Axetil Loaded Gastro retentive Floating Tablets Drug Invention Today 2010, 2(10),457-459
  10. Influence of Hydrophilic and Hydrophobic Polymers on Lamivudine Release from Matrix Tablets, American Journal of PharmTech Research. 2011; 1(2): 31-42.
  11. Cefuroxime Axetil Loaded Gastroretentive Floating TabletsBased on Hydrophilic Polymers: Preparation and In Vitro Evaluation Braz. Arch. Biol. Technol. v.55 n.2: pp. 269-275, Mar/Apr 2012.
  12. Formulation and Evaluation of Sustained Release Matrix Tablets of Zidovudine using Hydrophilic and Hydrophobic Polymers: AAPS Annual Meeting and Exposition, Chicago, USA. McCormick Place, Chicago, USA, 16 October 2012.
  13. Design, Development and Optimization of Gastro Retentive Floating Tablets of Cefixime Trihydrate:  Asian J. Chem. Vol. 25, No. 13 (2013), 7599-7606.
  14. Statistical Optimization of Intra-gastric Floating tablets of Cefixime Trihydrate Using Mixture Design, Int. J. Pharm. Sci. Rev. Res., 24(2), Jan – Feb 2014; n0 31, 195-201.
  15. Application of Central Composite Design for Optimization of Effervescent Floating Tablets Using Hydrophilic Polymers, Asian Journal of Pharmaceutical and Clinical Research 8 (1), 2015, 293-298
  16. Goodness of fit Model Dependent Approaches of Controlled Release Matrix Tablets of Zidovudine, Indian Journal of Pharmaceutical Education and Research | Vol 50 | Issue 1 | Jan-Mar, 2016.
  17. Parida G. K., Mohapatra S., Kar R. K. Solid lipid nanoparticles: a new approach of            Colloidal drug carrier World journal of pharmacy and pharmaceutical sciences      Volume 5, Issue 4, 2124-2142, 2016.

 Mrs. Sangeeta Mohanty

  1. Formulation & Invitro evaluation of Azithromycin mouth dissolving tablet using super disintegrants S.Mohanty, S.Patra,R.Mohapatra Research Journal of Pharmaceutical, Biological & ChemicalSciences (SCOPUS) RJPBCS, July-Sep 2013; 4(3):452-461
  2. Prep of 5 Florouracil microspheres for colonic drug delivery S.Mohanty, A.K.Panigrahi International Journal of Pharmacy (SCOPUS) Int J Pharm 2014; 4(3): 283-296
  3. Multiparticulate drug delivery system for colon targeting S.Mohanty, A.K.Panigrahi International Journal of Pharmacy & Pharmaceutical Sciences (SCOPUS) Int J Pharm Pharm Sci,2015;Vol 7, Issue 3, 433- 436
  4. Dissolution Enhancement of Seroquel by Solid Dispersion Techniques. Sangeeta Mohanty, Abhisek Pal, Asian journal of pharmaceutical and clinical research. (SCOPUS) Vol.9,Issue 4 July,2016, 284-287.